Edible Alchemy Blog

Benefits of Medicinal Mushrooms

Mushrooms have thousands of years of therapeutic use in traditional cultures; however, today, the literature is starting to emerge on both their mechanisms and the full range of applications. While much of the research has focused on their (a) antioxidant content; (b) ability to regulate the immune system; and (c) ability to combat cancer; they may also play roles in (d) reducing inflammation; (e) combating metabolic syndrome, including diabetes, obesity and cardiovascular disease; (f) combating pathogenic bacteria, viruses, parasites, and other fungi; (g) improving mood, cognitive function and reducing neurodegeneration; and (h) improving organ function.

The first three benefits are focused on because most medicinal mushrooms are rich sources of antioxidants and have the immunomodulatory ability. However, the ability of specific mushrooms to reduce inflammation and improve detoxification pathways which, in conjunction with the former effects, can have broad-reaching systemic health benefits. Rather than taking them in isolation, we can optimize a synergistic effect to help achieve optimal health by combining them.

However, we might encounter a common problem because their chitinous cell walls impede bioavailability or adequate absorption of their various bioactive compounds. Because of this issue, particular extraction methods are essential. For example, by utilizing a triple extraction method, the full spectrum can be isolated for maximum benefit.

Keep reading to learn the key benefits of various medicinal mushrooms and extraction methods to utilize these mushrooms to their fullest potential.

 

If you want to enter the realm of using mushrooms for their therapeutic effects, we have the appropriate product for you. Our organic therapeutic mushroom powders are some of the best on the market.

 

Due to our extraction methods, these mushrooms will have improved bioavailability, thus, improved benefits.

 

Benefits of Individual Medicinal Mushrooms

 

mushroom in a forest opening

 

Medicinal mushrooms are more than a low-calorie nutrient supplier. They also house many health benefits that could help remedy existing ailments and prevent new problems from arising.

Throughout this list, each point will cover the proven benefits of over ten mushroom types. That way, we have a better understanding of why they play an essential role in human health.

 

Related: Who Is Edible Alchemy?

 

Reishi (Ganoderma lucidum)

The Reishi mushroom is native to hot and humid areas of Asia. Other than this mushroom’s positive effects on testosterone, Reishi also has these benefits:

  • Antidiabetic
  • Anti-inflammatory
  • Antimicrobial & antiviral
  • Antioxidant
  • Anxiolytic
  • Hepatoprotective
  • Cardioprotective
  • Immunomodulatory
  • Improves microbiome
  • Mood enhancing
  • Reduces fatigue

 

Cordyceps (Ophiocordyceps sinensis)

A type of fungus commonly found on caterpillars in mountainous regions of China. A multitude of health benefits is provided by cordyceps, including:

  • Antidiabetic
  • Anti-inflammatory
  • Antioxidant
  • Athletic Performance
  • Hepatoprotective
  • Immunomodulatory
  • Promotes respiratory function

 

Related: Organic Cordyceps Extracted Mushroom Tinctures

 

Chaga (Inonotus obliquus)

For centuries, Chaga mushrooms have been utilized as a traditional medicine to boost overall health and immune systems. This mushroom also offers the following benefits:

  • Antidiabetic
  • Anti-inflammatory
  • Antioxidant
  • Athletic Performance
  • Cardioprotective
  • Immunomodulatory

 

Mesima (Phellinus linteus)

Also known as the Black Hoof Mushroom, Meisma was used in teas by past Chinese and Japanese royalty. Now it is used to potentially remedy ailments with the following benefits:

  • Anti-inflammatory
  • Antioxidant
  • Immunomodulatory

 

Lion's Mane (Hericium erinaceus)

Lion’s Manes are large and white mushrooms packed with various benefits like:

  • Antidiabetic
  • Anti-inflammatory 
  • Antioxidant
  • Cognitive enhancement
  • Immunomodulatory
  • Neuroprotective

 

Turkey Tail (Trametes versicolor)

For centuries, many have used this mushroom to treat a myriad of conditions naturally. Some of the Turkey Tail’s benefits and conditions that it treats include:

  • Anti-carcinogenic 
  • Anti-inflammatory 
  • Antimicrobial & antiviral
  • Antioxidant
  • Immunomodulatory
  • Improves microbiome

 

Maitake (Grifola frondosa)

Dancing mushrooms, or Maitake, have many positive health effects, including:

  • Antidiabetic
  • Anti-inflammatory 
  • Antioxidant
  • Immunomodulatory

 

Shiitake (Lentinula edodes)

These popular mushrooms are native to East Asia. Shiitake mushrooms are said to have many health benefits, including:

  • Antimicrobial & antiviral
  • Antioxidant
  • Cardioprotective
  • Cognitive enhancement
  • Immunomodulatory
  • Weight regulation

 

Agaricus Blazei (Agaricus subrufescens)

The Agracius Blazei is rich in immunomodulating polysaccharides (β-glucans). According to an investigation by the National Center for Biotechnology Information (NCBI), these mushrooms treat inflammatory bowel diseases in patients in addition to other areas like:

  • Antidiabetic
  • Antimicrobial & antiviral
  • Anti-inflammatory
  • Antioxidant
  • Immunomodulatory

 

Poria (Wolfiporia extensa)

Poria mushrooms contain chemicals that may reduce swelling, enhance immunity, and prevent cancer. Among the additional benefits are:

  • Anti-inflammatory
  • Antioxidant
  • Hepatoprotective
  • Immunomodulatory
  • Renoprotective

 

Agarikon (Laricifomes officinalis)

There are several benefits associated with this fungus:

  • Antimicrobial & antiviral
  • Anti-inflammatory
  • Immunomodulatory
  • Promotes respiratory function

 

Suehirotake (Schizophyllum commune)

The Split-Fold Mushroom (Suehirotake) has a polysaccharide structure, which stimulates T cells. Some of this mushroom’s demonstrated benefits include:

  • Anti-inflammatory
  • Antioxidant
  • Cardioprotective
  • Hepatoprotective
  • Immunomodulatory

 

Oyster Mushroom (Pleurotus ostreatus)

In addition to having a lot of protein and nutrients, Oyster Mushrooms also have the following benefits:

  • Antimicrobial
  • Antidiabetic
  • Anti-inflammatory 
  • Antioxidant
  • Cardioprotective
  • Immunomodulatory
  • Promotes respiratory function

 

True Tinder Polypore (Fomes fomentarius)

Polypores have been a source of medication for centuries for various cultures. Some of its beneficial properties include the following:

  • Analgesic
  • Anti-inflammatory
  • Antioxidant
  • Immunomodulatory

 

Organic Myceliated Brown Rice

 

Mycelium is grown on non-fruiting bodies such as brown rice and afterward grounded into a powder. Not only do we obtain the effects of the fruited mushroom, but we also benefit from the grains the mycelium is grown on.

Moreover, mycelium-centered byproducts increase our immunity by stimulating white blood cells.

 

Optimized Triple Extraction Method

 

To achieve the most therapeutic benefit out of the mushrooms, a triple extraction method is utilized, consisting of: fermentation, hot water extraction and alcohol extraction.  Fermentation is, unfortunately, a very time-consuming process and is not often used; however, by fermenting the mushrooms first, it improves the bioavailability of the polysaccharides, alkaloids, and triterpenoids (or terpenes).  Conducting an extraction using hot water helps to break down the chitin walls, which humans lack the proper enzymes to degrade; this liberates more polysaccharides, particularly the beta-glucans. This process is finished with an alcohol extraction of at least 100 days in organic, USP grade alcohol.  The literature on the extraction of bioactive compounds from mushrooms indicates that these are the most effective methods, and by applying all three, it helps to ensure that individuals receive the full spectrum of beneficial properties.

 

Related: Benefits of Our Mushroom Tinctures

 

Importance of Organic, USP Grade Alcohol

 

a hand holding a tincture bottle

 

As discussed before, alcohol provides one of the best methods of extracting the bioactive compounds from medicinal mushrooms, particularly those which are not water-soluble. Moreover, it helps to preserve these compounds, for improved shelf life. While any alcohol can technically achieve this, to an extent, by using United State Pharmacopeia (USP) grade, organic alcohol purity can be further ensured.  

If one is taking a product to improve their health, why would they settle for a substandard delivery medium?

USP grade alcohol is required to meet or exceed strict, pharmaceutical-grade standards, at a proof of at least 190. By choosing organic, not only does it help ensure purity of the product, for the individual, but also demonstrates a dedication to supporting a sustainable environment. While all alcohol is technically organic in the chemical sense, organic alcohol refers specifically to alcohol derived from sources which meet the legal definitions of organic certification.

 

Our therapeutic mushroom tinctures are triple extracted and take 100 days to make to give you the quality and purity that you need. Learn more by browsing our selection of tinctures.

 

References:

Abdullah, N., Ismail, S. M., Aminudin, N., Shuib, A. S., & Lau, B. F. (2012). Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities. Evidence-Based Complementary and Alternative Medicine: eCAM, 2012, 464238. 

Bae, M. J., See, H. J., Choi, G., Kang, C. Y., Shon, D. H., & Shin, H. S. (2016). Regulatory T cell induced by Poria cocos bark exert therapeutic effects in murine models of atopic dermatitis and food allergy. Mediators of Inflammation, 2016, 3472608. 

Barbieri, A., Quagliariello, V., Del Vecchio, V., Falco, M., Luciano, A., Amruthraj, N. J., … Arra, C. (2017). Anticancer and anti-inflammatory properties of Ganoderma lucidum extract effects on melanoma and triple-negative breast cancer treatment. Nutrients, 9(3), 210. 

Batra, P., Sharma, A. K., & Khajuria, R. (2013). Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): A bitter mushroom with amazing health benefits. International Journal of Medicinal Mushrooms, 15(12), 127-143. 

Chang, C. J., Lin, C. S., Lu, C. C., Martel, J., Ko, Y. F., Ojcius, D. M., … Lai, H. C. (2015). Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nature Communications, 6, 7489.

Chao, W., Deng, J. S., Li, P. Y., Liang, Y. C., & Huang, G. J. (2017). 3,4-dihydroxybenzalactone suppresses human non-small cell lung carcinoma cells metastasis via suppression of epithelial to mesenchymal transition, ROS-mediated PI3K/AKT/MAPK/MMP and NFκB signaling pathways. Molecules, 22, 537. 

Cheng, S., Swanson, K., Eliaz, I., McClintick, J. N., Sandusky, G. E., & Sliva, D. (2015). Pachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress. PLoS ONE, 10(4), e0122270. 

Cheng, J. H., Tsai, C. L., Lien, Y. Y., Lee, M. S., & Sheu, S. C. (2016). High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity. BMC Complementary and Alternative Medicine, 16, 170. 

Chou, Y. J., Kan, W. C., Chang, C. M., Peng, Y. J., Wang, H. Y., Yu, W. C., … Chuu, J. J. (2016). Renal protective effects of low molecular weight of Inonotus obliquus polysaccharide (LIOP) on HFD/STZ-induced nephropathy in mice. International Journal of Molecular Sciences, 17(9), 1535. 

Costa Fortes, R., & Carvalho Garbi Novaes, M. R. (2011). The effects of Agaricus sylvaticus fungi dietary supplementation on the metabolism and blood pressure of patients with colorectal cancer during post surgical phase. Nutrición hospitalaria, 26(1), 176-186. 

Dai, X., Stanilka, J M., Rowe, C. A., Esteves, E. A., Nieves, C. Jr., Spaiser, S. J., ... & Percival, S. S. (2015). Consuming Lentinula edodes (shiitake) mushrooms daily improves human immunity: a randomized dietary intervention in healthy young adults. Journal of the American College of Nutrition, 34(6), 478-487. 

Diao, B., Jin, W., & Yu, X. (2014). Protective effect of polysaccharides from Inonotus obliquus on streptozotocin-induced diabetic symptoms and their potential mechanisms in rats. Evidence-Based Complementary and Alternative Medicine : eCAM, 2014, 841496. 

Donatini, B. (2014). Control of oral human papillomavirus (HPV) by medicinal mushrooms, Trametes versicolor and Ganoderma lucidum: A preliminary clinical trial. International Journal of Medicinal Mushrooms, 16(5), 497-498.

Dresch, P., D´Aguanno, M. N., Rosam, K., Grienke, U., Rollinger, J. M., & Peintner, U. (2015). Fungal strain matters: Colony growth and bioactivity of the European medicinal polypores Fomes fomentarius, Fomitopsis pinicola and Piptoporus betulinus. AMB Express, 5, 4. 

Du, B., Yang, Y., Bian, Z., & Xu, B. (2017). Characterization and anti-inflammatory potential of an exopolysaccharide from submerged mycelial culture of Schizophyllum commune. Frontiers in Pharmacology, 8, 252. 

Elsayed, E. A., El Enshasy, H., Wadaan, M. A. M., & Aziz, R. (2014). Mushrooms: A potential natural source of anti-inflammatory compounds for medical applications. Mediators of Inflammation, 2014, 805841. 

Friedman, M. (2016). Mushroom polysaccharides: Chemistry and antiobesity, antidiabetes, anticancer, and antibiotic properties in cells, rodents, and humans. Foods, 5(4), 80. 

Gao, D., Pang, J. Y., Zhang, C. E., Li, C. Y., Tu, C., Zhang, H. Z., … Wang, J. B. (2016). Poria attenuates idiosyncratic liver injury induced by Polygoni multiflori Radix praeparata. Frontiers in Pharmacology, 7, 386. 

Guggenheim, A. G., Wright, K. M., & Zwickey, H. L. (2014). Immune modulation from five major mushrooms: Application to integrative oncology. Integrative Medicine: A Clinician’s Journal, 13(1), 32–44. 

Jayasuriya, W. J., Wanigatunge, C. A., Fernando, G. H., Abeytunga, D. T., & Suresh, T. S. (2015). Hypoglycaemic activity of culinary Pleurotus ostreatus and P. cystidiosus mushrooms in healthy volunteers and type 2 diabetic patients on diet control and the possible mechanisms of action. Phytotherapy Research, 29(2), 303-309. 

Jedinak, A., Dudhgaonkar, S., Wu, Q., Simon, J., & Sliva, D. (2011). Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-κB and AP-1 signaling. Nutrition Journal, 10, 52. 

Jesenak, M., Hrubisko, M., Majtan, J., Rennerova, Z., & Banovcin, P. (2014). Anti-allergic effect of Pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. Phytotherapy Research, 28(3), 471-474. 

Jiang, S., Wang, Y., & Zhang, X. (2016). Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities. Experimental and Therapeutic Medicine, 12(1), 513–517. 

Kao, C. H. J., Bishop, K. S., Xu, Y., Han, D. Y., Murray, P. M., Marlow, G. J., & Ferguson, L. R. (2016). Identification of potential anticancer activities of novel Ganoderma lucidum extracts using gene expression and pathway network analysis. Genomics Insights, 9, 1–16. 

Kim, S. H., Jakhar, R., & Kang, S. C. (2015). Apoptotic properties of polysaccharide isolated from fruiting bodies of medicinal mushroom Fomes fomentarius in human lung carcinoma cell line. Saudi Journal of Biological Sciences, 22(4), 484–490. 

Kobayashi, H., Motoyoshi, N., Itagaki, T., Tabata, K., Suzuki, T., & Inokuchi, N. (2013). The inhibition of human tumor cell proliferation by RNase Pol, a member of the RNase T1 family, from Pleurotus ostreatus. Bioscience, Biotechnology, and Biochemistry, 77(7), 1486-1491. 

Lee, K. F., Chen, J. H., Teng, C. C., Shen, C. H., Hsieh, M. C., Lu, C. C., … Kuo, H. C. (2014). Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine. International Journal of Molecular Sciences, 15(9), 15073–15089. 

Lee, K., Kuo, H., Shen, C., Lu, C., Huang, W., Hsieh, M., … Tung, S. (2017). A proteomics approach to identifying novel protein targets involved in erinacine A–mediated inhibition of colorectal cancer cells’ aggressiveness. Journal of Cellular and Molecular Medicine, 21(3), 588–599. 

Lee, S. R., Lee, S., Moon, E., Park, H. J., Park, H. B., & Kim, K. H. (2017). Bioactivity-guided isolation of anti-inflammatory triterpenoids from the sclerotia of Poria cocos using LPS-stimulated Raw264.7 cells. Bioorganic Chemistry, 70, 94-99. 

Lemieszek, M., & Rzeski, W. (2012). Anticancer properties of polysaccharides isolated from fungi of the Basidiomycetes class. Contemporary Oncology, 16(4), 285–289. 

Li, K., Zhuo, C., Teng, C., Yu, S., Wang, X., Hu, Y., Ren, G., Yu, M., & Qu, J. (2016). Effects of Ganoderma lucidum polysaccharides on chronic pancreatitis and intestinal microbiota in mice. International Journal of Biological Macromolecules, 93(Pt A), 904-912. 

Liang, B., Guo, Z., Xie, F., & Zhao, A. (2013). Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complementary and Alternative Medicine, 13, 253. 

Liu, J., Du, C., Wang, Y., & Yu, Z. (2015). Anti-fatigue activities of polysaccharides extracted from Hericium erinaceus. Experimental and Therapeutic Medicine, 9(2), 483–487. 

Liu, Y. H., Lin, Y. S., Lin, K. L., Lu, Y. L., Chen, C. H., Chien, M. Y., … Hou, W. C. (2015). Effects of hot-water extracts from Ganoderma lucidum residues and solid-state fermentation residues on prebiotic and immune-stimulatory activities in vitro and the powdered residues used as broiler feed additives in vivo. Botanical Studies, 56, 17. 

Lu, C. L., Wang, J. P., & Chen, S. N. (2010). Protease purified from Schizophyllum commune culture broth digests fibrins without activating plasminogen. American Journal of Chinese Medicine, 38(6), 1223-1231. 

Lu, H., Yang, Y., Gad, E., Wenner, C. A., Chang, A., Larson, E. R., … Disis, M. L. (2011). Polysaccharide krestin is a novel TLR2 agonist that mediates inhibition of tumor growth via stimulation of CD8 T cells and NK cells. Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 17(1), 67–76. 

Maiti, S., Mallick, S. K., Bhutia, S. K., Behera, B., Mandal, M., & Maiti, T. K. (2011). Antitumor effect of culinary-medicinal oyster mushroom, Pleurotus ostreatus (Jacq.: Fr.) P. Kumm., derived protein fraction on tumor-bearing mice models. International Journal of Medicinal Mushrooms, 13(5), 427-440. 

Matsunaga, Y., Wahyudiono, Machmudah, S., Askin, R., Quitain, A. T., Sasaki, M., & Goto, M. (2013). Hydrothermal extraction and micronization of polysaccharides from Ganoderma lucidum in a one-step process. Asia-Pacific Journal of Chemical Engineering, 9(1), 10pp. 

Meneses, M. E., Martínez-Carrera, D., Torres, N., Sánchez-Tapia, M., Aguilar-López, M., Morales, P., … Tovar, A. R. (2016). Hypocholesterolemic properties and prebiotic effects of Mexican Ganoderma lucidum in C57BL/6 mice. PLoS ONE, 11(7), e0159631. 

Nguyen, T. K., Im, K. H., Choi, J., Shin, P. G., & Lee, T. S. (2016). Evaluation of antioxidant, anti-cholinesterase, and anti-inflammatory effects of culinary mushroom Pleurotus pulmonarius. Mycobiology, 44(4), 291–301. 

Nimri, L., Spivak, O., Tal, D., Schälling, D., Peri, I., Graeve, L., … Schwartz, B. (2017). A recombinant fungal compound induces anti-proliferative and pro-apoptotic effects on colon cancer cells. Oncotarget, 8(17), 28854–28864. 

Nowacka, N., Nowak, R., Drozd, M., Olech, M., Los, R., & Malm, A. (2015). Antibacterial, antiradical potential and phenolic compounds of thirty-one Polish mushrooms. PLoS ONE, 10(10), e0140355. 

Pallav, K., Dowd, S. E., Villafuerte, J., Yang, X., Kabbani, T., Hansen, J., ... & Kelly, C. P. (2014). Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: A randomized clinical trial. Gut Microbes, 5(4), 458-467. 

Papaspyridi, L. M., Aligiannis, N., Topakas, E., Christakopoulos, P., Skaltsounis, A. L., & Fokialakis, N. (2012). Submerged fermentation of the edible mushroom Pleurotus ostreatus in a batch stirred tank bioreactor as a promising alternative for the effective production of bioactive metabolites. Molecules. 17(3):2714–2724. 

Park, K. M., Kwon, K. M., & Lee, S. H. (2015). Evaluation of the antioxidant activities and tyrosinase inhibitory property from mycelium culture extracts. Evidence-Based Complementary and Alternative Medicine : eCAM, 2015, 616298. 

Pennerman, K. K., Yin, G., & Bennett, J. W. (2015). Health effects of small volatile compounds from East Asian medicinal mushrooms. Mycobiology, 43(1), 9–13. 

Reis, F. S., Martins, A., Barros, L., & Ferreira, I. C. (2012). Antioxidant properties and phenolic profile of the most widely appreciated cultivated mushrooms: A comparative study between in vivo and in vitro samples. Food and Chemistry Toxicology, 50(5), 1201-1207.

Schulman, A., Chaimowitz, M., Choudhury, M., Eshghi, M., & Konno, S. (2016). Antioxidant and renoprotective effects of mushroom extract: Implication in prevention of nephrolithiasis. Journal of Clinical Medicine Research, 8(12), 908–915. 

Sekhon, B. K., Roubin, R. H., Li, Y., Devi, P. B., Nammi, S., Fan, K., & Sze, D. M. (2016). Evaluation of selected immunomodulatory glycoproteins as an adjunct to cancer immunotherapy. PLoS ONE, 11(1), e0146881. 

Seo, D. W., Yi, Y. J., Lee, M. S., Yun, B. S., & Lee, S. M. (2015). Differential modulation of lipopolysaccharide-induced inflammatory cytokine production by and antioxidant activity of fomentariol in RAW264.7 cells. Mycobiology, 43(4), 450–457. 

Sharma, S. K., Gautam, N., & Atri, N. S. (2015). Optimized extraction, composition, antioxidant and antimicrobial activities of exo and intracellular polysaccharides from submerged culture of Cordyceps cicadae. BMC Complementary and Alternative Medicine, 15, 446. 

Su, H. H., Chu, Y. C., Liao, J. M., Wang, Y. H., Jan, M. S., Lin, C. W., … Huang, S. S. (2017). Phellinus linteus mycelium alleviates myocardial ischemia-reperfusion injury through autophagic regulation. Frontiers in Pharmacology, 8, 175. 

Tan, Y. S., Baskaran, A., Nallathamby, N., Chua, K. H., Kuppusamy, U. R., & Sabaratnam, V. (2015). Influence of customized cooking methods on the phenolic contents and antioxidant activities of selected species of oyster mushrooms (Pleurotus spp.). Journal of Food Science and Technology, 52(5), 3058–3064. 

Therkelsen, S. P., Hetland, G., Lyberg, T., Lygren, I., & Johnson, E. (2016). Effect of the medicinal Agaricus blazei murill-based mushroom extract, AndoSanTM, on symptoms, fatigue and quality of life in patients with crohn’s disease in a randomized single-blinded placebo controlled study. PLoS ONE, 11(7), e0159288. 

Torkelson, C. J., Sweet, E., Martzen, M. R., Sasagawa, M., Wenner, C. A., Gay, J., … Standish, L. J. (2012). Phase 1 clinical trial of Trametes versicolor in women with breast cancer. ISRN Oncology, 2012, 251632. 

Trovato, A., Siracusa, R., Di Paola, R., Scuto, M., Ontario, M. L., Bua, O., … Calabrese, V. (2016). Redox modulation of cellular stress response and lipoxin A4 expression by Hericium erinaceus in rat brain: Relevance to alzheimer’s disease pathogenesis. Immunity & Ageing : I & A, 13, 23. 

Tseng, T. H., Lin, W. L., Chen, Z. H., Lee, Y. J., Shie, M. S., Lee, K. F., … Kuo, H. C. (2016). Moniliformediquinone as a potential therapeutic agent, inactivation of hepatic stellate cell and inhibition of liver fibrosis in vivo. Journal of Translational Medicine, 14(1), 263. 

Tuli, H. S., Sandhu, S. S., & Sharma, A. K. (2014). Pharmacological and therapeutic potential of Cordyceps with special reference to cordycepin. 3 Biotech, 4(1), 1–12. 

Val, C. H., Brant, F., Miranda, A. S., Rodrigues, F. G., Oliveira, B. C. L., Santos, E. A., … Machado, F. S. (2015). Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria. Malaria Journal, 14, 311. 

Valadares, F., Garbi Novaes, M. R. C., & Cañete, R. (2013). Effect of Agaricus sylvaticus supplementation on nutritional status and adverse events of chemotherapy of breast cancer: A randomized, placebo-controlled, double-blind clinical trial. Indian Journal of Pharmacology, 45(3), 217–222. 

Valverde, M. E., Hernández-Pérez, T., & Paredes-López, O. (2015). Edible mushrooms: Improving human health and promoting quality life. International Journal of Microbiology, 2015, 376387. 

Vamanu, E. (2012). Biological activities of the polysaccharides produced in submerged culture of two edible Pleurotus ostreatus mushrooms. Journal of Biomedicine and Biotechnology, 2012, 565974. 

Vazirian, M., Faridfar, S., & Eftekhari, M. (2016). “Gharikon”/”Agharikon” a valuable medicinal mushroom in Iranian traditional medicine. Iranian Journal of Medical Sciences, 41(3 Suppl), S34. 

Vitak, T., Yurkiv, B., Wasser, S., Nevo, E., & Sybirna, N. (2017). Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus. World Journal of Diabetes, 8(5), 187–201. 

Wang, H., Fu, Z., & Han, C. (2013). The medicinal values of culinary-medicinal royal sun mushroom (Agaricus blazei Murrill). Evidence-Based Complementary and Alternative Medicine : eCAM, 2013, 842619. 

Wang, F., Zhou, Z., Ren, X., Wang, Y., Yang, R., Luo, J., & Strappe, P. (2015). Effect of Ganoderma lucidum spores intervention on glucose and lipid metabolism gene expression profiles in type 2 diabetic rats. Lipids in Health and Disease, 14, 49. 

Wang, P. W., Hung, Y. C., Li, W. T., Yeh, C. T., & Pan, T. L. (2016). Systematic revelation of the protective effect and mechanism of Cordycep sinensis on diethylnitrosamine-induced rat hepatocellular carcinoma with proteomics. Oncotarget, 7(37), 60270–60289. 

Wei, W., Shu, S., Zhu, W., Xiong, Y., & Peng, F. (2016). The kinome of edible and medicinal fungus Wolfiporia cocos. Frontiers in Microbiology, 7, 1495. 

Wisitrassameewong, K., Karunarathna, S. C., Thongklang, N., Zhao, R., Callac, P., Moukha, S., … Hyde, K. D. (2012). Agaricus subrufescens: A review. Saudi Journal of Biological Sciences, 19(2), 131–146. 

Wu, J. Y., Chen, X., & Siu, K. C. (2014). Isolation and structure characterization of an antioxidative glycopeptide from mycelial culture broth of a medicinal fungus. International Journal of Molecular Sciences, 15(10), 17318–17332. 

Xu, Z., Chen, X., Zhong, Z., Chen, L., & Wang, Y. (2011). Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities. American Journal of Chinese Medicine, 39(1), 15-27. 

Zhang, J., An, S., Hu, W., Teng, M., Wang, X., Qu, Y., … Wang, D. (2016). The neuroprotective properties of Hericium erinaceus in glutamate-damaged differentiated PC12 Cells and an alzheimer’s disease mouse model. International Journal of Molecular Sciences, 17(11), 1810. 

Zhao, H., Zhang, Q., Zhao, L., Huang, X., Wang, J., & Kang, X. (2012). Spore powder of Ganoderma lucidum improves cancer-related fatigue in breast cancer patients undergoing endocrine therapy: A pilot clinical trial. Evidence-Based Complementary and Alternative Medicine: eCAM, 2012, 809614.

The Edible Alchemy Community's Impact

1% of every Edible Alchemy purchase is donated to a nonprofit of your choice. Check out the impact the Edible Alchemy community is making below.