Benefits of Mushrooms

Benefits of Medicinal Mushrooms

Mushrooms have thousands of years of therapeutic use traditional cultures; however, today, the literature is starting to emerge on both their mechanisms and full range of applications.  While much of the research has focused on their (a) antioxidant content; (b) ability to regulate the immune system; and (c) ability to combat cancer; they may also play roles in (d) reducing inflammation; (e) combating metabolic syndrome, including diabetes, obesity and cardiovascular disease; (f) combating pathogenic bacteria, viruses, parasites and other fungi; (g) improving mood, cognitive function and reducing neurodegeneration; and (h) improving organ function.  

 

The first three are focused on is because most medicinal mushrooms are rich sources of antioxidants and have immunomodulatory ability.  However, the ability of specific mushrooms to reduce inflammation and improve detoxification pathways which, in conjunction with the former effects, can have broad reaching systemic health benefits.  Rather than taking them in isolation, by combining them together, a synergistic effect can be optimized to help achieve optimal health.  

 

A common problem, however, is that their chitinous cell walls impede bioavailability, or adequate absorption of their various bioactive compounds.  This makes the extraction method essential. By utilizing a triple extraction method, the full spectrum can be isolated for maximum benefit.

Benefits of Individual Medicinal Mushrooms

Reishi (Ganoderma lucidum)

  • Antidiabetic
  • Anti-inflammatory
  • Antimicrobial & antiviral
  • Antioxidant
  • Anxiolytic
  • Hepatoprotective
  • Cardioprotective
  • Immunomodulatory
  • Improves microbiome
  • Mood enhancing
  • Reduces fatigue

Cordyceps (Ophiocordyceps sinensis)

  • Antidiabetic
  • Anti-inflammatory
  • Antioxidant
  • Athletic Performance
  • Hepatoprotective
  • Immunomodulatory
  • Promotes respiratory function

Chaga (Inonotus obliquus)

  • Antidiabetic
  • Anti-inflammatory
  • Antioxidant
  • Athletic Performance
  • Cardioprotective
  • Immunomodulatory

Mesima (Phellinus linteus)

  • Anti-inflammatory
  • Antioxidant
  • Immunomodulatory

Lion's Mane (Hericium erinaceus)

  • Antidiabetic
  • Anti-inflammatory 
  • Antioxidant
  • Cognitive enhancement
  • Immunomodulatory
  • Neuroprotective

Turkey Tail (Trametes versicolor)

  • Anti-carcinogenic 
  • Anti-inflammatory 
  • Antimicrobial & antiviral
  • Antioxidant
  • Immunomodulatory
  • Improves microbiome

Maitake (Grifola frondosa)

  • Antidiabetic
  • Anti-inflammatory 
  • Antioxidant
  • Immunomodulatory

Shiitake (Lentinula edodes)

  • Antimicrobial & antiviral
  • Antioxidant
  • Cardioprotective
  • Cognitive enhancement
  • Immunomodulatory
  • Weight regulation

Agaricus Blazei (Agaricus subrufescens)

  • Antidiabetic
  • Antimicrobial & antiviral
  • Anti-inflammatory
  • Antioxidant
  • Immunomodulatory

Poria (Wolfiporia extensa)

  • Anti-inflammatory
  • Antioxidant
  • Hepatoprotective
  • Immunomodulatory
  • Renoprotective

Agarikon (Laricifomes officinalis)

  • Antimicrobial & antiviral
  • Anti-inflammatory
  • Immunomodulatory
  • Promotes respiratory function

Suehirotake (Schizophyllum commune)

  • Anti-inflammatory
  • Antioxidant
  • Cardioprotective
  • Hepatoprotective
  • Immunomodulatory

Oyster Mushroom (Pleurotus ostreatus)

  • Antimicrobial
  • Antidiabetic
  • Anti-inflammatory 
  • Antioxidant
  • Cardioprotective
  • Immunomodulatory
  • Promotes respiratory function

True Tinder Polypore (Fomes fomentarius)

  • Analgesic
  • Anti-inflammatory
  • Antioxidant
  • Immunomodulatory

Organic Myceliated Brown Rice

 

Optimized Triple Extraction Method

In order to achieve the most therapeutic benefit out of the mushrooms, a triple extraction method is utilized, consisting of: fermentation, hot water extraction and alcohol extraction.  Fermentation is unfortunately a very time-consuming process and is not often used; however, by fermenting the mushrooms first, it improves the bioavailability of the polysaccharides, alkaloids and triterpenoids (or terpenes).  Conducting an extraction using hot water helps to break down the chitin walls, which humans lack the proper enzymes to degrade; this liberates more polysaccharides, particularly the beta-glucans. This process is finished with an alcohol extraction of at least 100 days in organic, USP grade alcohol.  The literature on the extraction of bioactive compounds from mushrooms indicates that these are the most effective methods and by applying all three, it helps to ensure that individuals receive the full spectrum of beneficial properties.

Importance of Organic, USP Grade Alcohol 

As discussed before, alcohol provides one of the best methods of extracting the bioactive compounds from medicinal mushrooms, particularly those which are not water soluble.  Moreover, it helps to preserve these compounds, for improved shelf life. While any alcohol can technically achieve this, to an extent, by using United State Pharmacopeia (USP) grade, organic alcohol purity can be further ensured.  

If one is taking a product to improve their health, why would they settle for a substandard delivery medium?

USP grade alcohol is required to meet or exceed strict, pharmaceutical grade standards, at a proof of at least 190.  By choosing organic, not only does it help ensure purity of the product, for the individual, but also demonstrates a dedication to supporting a sustainable environment.   While all alcohol is technically organic in the chemical sense, organic alcohol refers specifically to alcohol derived from sources which meet the legal definitions of organic certification.

References:

Abdullah, N., Ismail, S. M., Aminudin, N., Shuib, A. S., & Lau, B. F. (2012). Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities. Evidence-Based Complementary and Alternative Medicine: eCAM, 2012, 464238. 

Bae, M. J., See, H. J., Choi, G., Kang, C. Y., Shon, D. H., & Shin, H. S. (2016). Regulatory T cell induced by Poria cocos bark exert therapeutic effects in murine models of atopic dermatitis and food allergy. Mediators of Inflammation, 2016, 3472608. 

Barbieri, A., Quagliariello, V., Del Vecchio, V., Falco, M., Luciano, A., Amruthraj, N. J., … Arra, C. (2017). Anticancer and anti-inflammatory properties of Ganoderma lucidum extract effects on melanoma and triple-negative breast cancer treatment. Nutrients, 9(3), 210. 

Batra, P., Sharma, A. K., & Khajuria, R. (2013). Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): A bitter mushroom with amazing health benefits. International Journal of Medicinal Mushrooms, 15(12), 127-143. 

Chang, C. J., Lin, C. S., Lu, C. C., Martel, J., Ko, Y. F., Ojcius, D. M., … Lai, H. C. (2015). Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nature Communications, 6, 7489.

Chao, W., Deng, J. S., Li, P. Y., Liang, Y. C., & Huang, G. J. (2017). 3,4-dihydroxybenzalactone suppresses human non-small cell lung carcinoma cells metastasis via suppression of epithelial to mesenchymal transition, ROS-mediated PI3K/AKT/MAPK/MMP and NFκB signaling pathways. Molecules, 22, 537. 

Cheng, S., Swanson, K., Eliaz, I., McClintick, J. N., Sandusky, G. E., & Sliva, D. (2015). Pachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress. PLoS ONE, 10(4), e0122270. 

Cheng, J. H., Tsai, C. L., Lien, Y. Y., Lee, M. S., & Sheu, S. C. (2016). High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity. BMC Complementary and Alternative Medicine, 16, 170. 

Chou, Y. J., Kan, W. C., Chang, C. M., Peng, Y. J., Wang, H. Y., Yu, W. C., … Chuu, J. J. (2016). Renal protective effects of low molecular weight of Inonotus obliquus polysaccharide (LIOP) on HFD/STZ-induced nephropathy in mice. International Journal of Molecular Sciences, 17(9), 1535. 

Costa Fortes, R., & Carvalho Garbi Novaes, M. R. (2011). The effects of Agaricus sylvaticus fungi dietary supplementation on the metabolism and blood pressure of patients with colorectal cancer during post surgical phase. Nutrición hospitalaria, 26(1), 176-186. 

Dai, X., Stanilka, J M., Rowe, C. A., Esteves, E. A., Nieves, C. Jr., Spaiser, S. J., ... & Percival, S. S. (2015). Consuming Lentinula edodes (shiitake) mushrooms daily improves human immunity: a randomized dietary intervention in healthy young adults. Journal of the American College of Nutrition, 34(6), 478-487. 

Diao, B., Jin, W., & Yu, X. (2014). Protective effect of polysaccharides from Inonotus obliquus on streptozotocin-induced diabetic symptoms and their potential mechanisms in rats. Evidence-Based Complementary and Alternative Medicine : eCAM, 2014, 841496. 

Donatini, B. (2014). Control of oral human papillomavirus (HPV) by medicinal mushrooms, Trametes versicolor and Ganoderma lucidum: A preliminary clinical trial. International Journal of Medicinal Mushrooms, 16(5), 497-498.

Dresch, P., D´Aguanno, M. N., Rosam, K., Grienke, U., Rollinger, J. M., & Peintner, U. (2015). Fungal strain matters: Colony growth and bioactivity of the European medicinal polypores Fomes fomentarius, Fomitopsis pinicola and Piptoporus betulinus. AMB Express, 5, 4. 

Du, B., Yang, Y., Bian, Z., & Xu, B. (2017). Characterization and anti-inflammatory potential of an exopolysaccharide from submerged mycelial culture of Schizophyllum commune. Frontiers in Pharmacology, 8, 252. 

Elsayed, E. A., El Enshasy, H., Wadaan, M. A. M., & Aziz, R. (2014). Mushrooms: A potential natural source of anti-inflammatory compounds for medical applications. Mediators of Inflammation, 2014, 805841. 

Friedman, M. (2016). Mushroom polysaccharides: Chemistry and antiobesity, antidiabetes, anticancer, and antibiotic properties in cells, rodents, and humans. Foods, 5(4), 80. 

Gao, D., Pang, J. Y., Zhang, C. E., Li, C. Y., Tu, C., Zhang, H. Z., … Wang, J. B. (2016). Poria attenuates idiosyncratic liver injury induced by Polygoni multiflori Radix praeparata. Frontiers in Pharmacology, 7, 386. 

Guggenheim, A. G., Wright, K. M., & Zwickey, H. L. (2014). Immune modulation from five major mushrooms: Application to integrative oncology. Integrative Medicine: A Clinician’s Journal, 13(1), 32–44. 

Jayasuriya, W. J., Wanigatunge, C. A., Fernando, G. H., Abeytunga, D. T., & Suresh, T. S. (2015). Hypoglycaemic activity of culinary Pleurotus ostreatus and P. cystidiosus mushrooms in healthy volunteers and type 2 diabetic patients on diet control and the possible mechanisms of action. Phytotherapy Research, 29(2), 303-309. 

Jedinak, A., Dudhgaonkar, S., Wu, Q., Simon, J., & Sliva, D. (2011). Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-κB and AP-1 signaling. Nutrition Journal, 10, 52. 

Jesenak, M., Hrubisko, M., Majtan, J., Rennerova, Z., & Banovcin, P. (2014). Anti-allergic effect of Pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. Phytotherapy Research, 28(3), 471-474. 

Jiang, S., Wang, Y., & Zhang, X. (2016). Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities. Experimental and Therapeutic Medicine, 12(1), 513–517. 

Kao, C. H. J., Bishop, K. S., Xu, Y., Han, D. Y., Murray, P. M., Marlow, G. J., & Ferguson, L. R. (2016). Identification of potential anticancer activities of novel Ganoderma lucidum extracts using gene expression and pathway network analysis. Genomics Insights, 9, 1–16. 

Kim, S. H., Jakhar, R., & Kang, S. C. (2015). Apoptotic properties of polysaccharide isolated from fruiting bodies of medicinal mushroom Fomes fomentarius in human lung carcinoma cell line. Saudi Journal of Biological Sciences, 22(4), 484–490. 

Kobayashi, H., Motoyoshi, N., Itagaki, T., Tabata, K., Suzuki, T., & Inokuchi, N. (2013). The inhibition of human tumor cell proliferation by RNase Pol, a member of the RNase T1 family, from Pleurotus ostreatus. Bioscience, Biotechnology, and Biochemistry, 77(7), 1486-1491. 

Lee, K. F., Chen, J. H., Teng, C. C., Shen, C. H., Hsieh, M. C., Lu, C. C., … Kuo, H. C. (2014). Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine. International Journal of Molecular Sciences, 15(9), 15073–15089. 

Lee, K., Kuo, H., Shen, C., Lu, C., Huang, W., Hsieh, M., … Tung, S. (2017). A proteomics approach to identifying novel protein targets involved in erinacine A–mediated inhibition of colorectal cancer cells’ aggressiveness. Journal of Cellular and Molecular Medicine, 21(3), 588–599. 

Lee, S. R., Lee, S., Moon, E., Park, H. J., Park, H. B., & Kim, K. H. (2017). Bioactivity-guided isolation of anti-inflammatory triterpenoids from the sclerotia of Poria cocos using LPS-stimulated Raw264.7 cells. Bioorganic Chemistry, 70, 94-99. 

Lemieszek, M., & Rzeski, W. (2012). Anticancer properties of polysaccharides isolated from fungi of the Basidiomycetes class. Contemporary Oncology, 16(4), 285–289. 

Li, K., Zhuo, C., Teng, C., Yu, S., Wang, X., Hu, Y., Ren, G., Yu, M., & Qu, J. (2016). Effects of Ganoderma lucidum polysaccharides on chronic pancreatitis and intestinal microbiota in mice. International Journal of Biological Macromolecules, 93(Pt A), 904-912. 

Liang, B., Guo, Z., Xie, F., & Zhao, A. (2013). Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complementary and Alternative Medicine, 13, 253. 

Liu, J., Du, C., Wang, Y., & Yu, Z. (2015). Anti-fatigue activities of polysaccharides extracted from Hericium erinaceus. Experimental and Therapeutic Medicine, 9(2), 483–487. 

Liu, Y. H., Lin, Y. S., Lin, K. L., Lu, Y. L., Chen, C. H., Chien, M. Y., … Hou, W. C. (2015). Effects of hot-water extracts from Ganoderma lucidum residues and solid-state fermentation residues on prebiotic and immune-stimulatory activities in vitro and the powdered residues used as broiler feed additives in vivo. Botanical Studies, 56, 17. 

Lu, C. L., Wang, J. P., & Chen, S. N. (2010). Protease purified from Schizophyllum commune culture broth digests fibrins without activating plasminogen. American Journal of Chinese Medicine, 38(6), 1223-1231. 

Lu, H., Yang, Y., Gad, E., Wenner, C. A., Chang, A., Larson, E. R., … Disis, M. L. (2011). Polysaccharide krestin is a novel TLR2 agonist that mediates inhibition of tumor growth via stimulation of CD8 T cells and NK cells. Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 17(1), 67–76. 

Maiti, S., Mallick, S. K., Bhutia, S. K., Behera, B., Mandal, M., & Maiti, T. K. (2011). Antitumor effect of culinary-medicinal oyster mushroom, Pleurotus ostreatus (Jacq.: Fr.) P. Kumm., derived protein fraction on tumor-bearing mice models. International Journal of Medicinal Mushrooms, 13(5), 427-440. 

Matsunaga, Y., Wahyudiono, Machmudah, S., Askin, R., Quitain, A. T., Sasaki, M., & Goto, M. (2013). Hydrothermal extraction and micronization of polysaccharides from Ganoderma lucidum in a one-step process. Asia-Pacific Journal of Chemical Engineering, 9(1), 10pp. 

Meneses, M. E., Martínez-Carrera, D., Torres, N., Sánchez-Tapia, M., Aguilar-López, M., Morales, P., … Tovar, A. R. (2016). Hypocholesterolemic properties and prebiotic effects of Mexican Ganoderma lucidum in C57BL/6 mice. PLoS ONE, 11(7), e0159631. 

Nguyen, T. K., Im, K. H., Choi, J., Shin, P. G., & Lee, T. S. (2016). Evaluation of antioxidant, anti-cholinesterase, and anti-inflammatory effects of culinary mushroom Pleurotus pulmonarius. Mycobiology, 44(4), 291–301. 

Nimri, L., Spivak, O., Tal, D., Schälling, D., Peri, I., Graeve, L., … Schwartz, B. (2017). A recombinant fungal compound induces anti-proliferative and pro-apoptotic effects on colon cancer cells. Oncotarget, 8(17), 28854–28864. 

Nowacka, N., Nowak, R., Drozd, M., Olech, M., Los, R., & Malm, A. (2015). Antibacterial, antiradical potential and phenolic compounds of thirty-one Polish mushrooms. PLoS ONE, 10(10), e0140355. 

Pallav, K., Dowd, S. E., Villafuerte, J., Yang, X., Kabbani, T., Hansen, J., ... & Kelly, C. P. (2014). Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: A randomized clinical trial. Gut Microbes, 5(4), 458-467. 

Papaspyridi, L. M., Aligiannis, N., Topakas, E., Christakopoulos, P., Skaltsounis, A. L., & Fokialakis, N. (2012). Submerged fermentation of the edible mushroom Pleurotus ostreatus in a batch stirred tank bioreactor as a promising alternative for the effective production of bioactive metabolites. Molecules. 17(3):2714–2724. 

Park, K. M., Kwon, K. M., & Lee, S. H. (2015). Evaluation of the antioxidant activities and tyrosinase inhibitory property from mycelium culture extracts. Evidence-Based Complementary and Alternative Medicine : eCAM, 2015, 616298. 

Pennerman, K. K., Yin, G., & Bennett, J. W. (2015). Health effects of small volatile compounds from East Asian medicinal mushrooms. Mycobiology, 43(1), 9–13. 

Reis, F. S., Martins, A., Barros, L., & Ferreira, I. C. (2012). Antioxidant properties and phenolic profile of the most widely appreciated cultivated mushrooms: A comparative study between in vivo and in vitro samples. Food and Chemistry Toxicology, 50(5), 1201-1207.

Schulman, A., Chaimowitz, M., Choudhury, M., Eshghi, M., & Konno, S. (2016). Antioxidant and renoprotective effects of mushroom extract: Implication in prevention of nephrolithiasis. Journal of Clinical Medicine Research, 8(12), 908–915. 

Sekhon, B. K., Roubin, R. H., Li, Y., Devi, P. B., Nammi, S., Fan, K., & Sze, D. M. (2016). Evaluation of selected immunomodulatory glycoproteins as an adjunct to cancer immunotherapy. PLoS ONE, 11(1), e0146881. 

Seo, D. W., Yi, Y. J., Lee, M. S., Yun, B. S., & Lee, S. M. (2015). Differential modulation of lipopolysaccharide-induced inflammatory cytokine production by and antioxidant activity of fomentariol in RAW264.7 cells. Mycobiology, 43(4), 450–457. 

Sharma, S. K., Gautam, N., & Atri, N. S. (2015). Optimized extraction, composition, antioxidant and antimicrobial activities of exo and intracellular polysaccharides from submerged culture of Cordyceps cicadae. BMC Complementary and Alternative Medicine, 15, 446. 

Su, H. H., Chu, Y. C., Liao, J. M., Wang, Y. H., Jan, M. S., Lin, C. W., … Huang, S. S. (2017). Phellinus linteus mycelium alleviates myocardial ischemia-reperfusion injury through autophagic regulation. Frontiers in Pharmacology, 8, 175. 

Tan, Y. S., Baskaran, A., Nallathamby, N., Chua, K. H., Kuppusamy, U. R., & Sabaratnam, V. (2015). Influence of customized cooking methods on the phenolic contents and antioxidant activities of selected species of oyster mushrooms (Pleurotus spp.). Journal of Food Science and Technology, 52(5), 3058–3064. 

Therkelsen, S. P., Hetland, G., Lyberg, T., Lygren, I., & Johnson, E. (2016). Effect of the medicinal Agaricus blazei murill-based mushroom extract, AndoSanTM, on symptoms, fatigue and quality of life in patients with crohn’s disease in a randomized single-blinded placebo controlled study. PLoS ONE, 11(7), e0159288. 

Torkelson, C. J., Sweet, E., Martzen, M. R., Sasagawa, M., Wenner, C. A., Gay, J., … Standish, L. J. (2012). Phase 1 clinical trial of Trametes versicolor in women with breast cancer. ISRN Oncology, 2012, 251632. 

Trovato, A., Siracusa, R., Di Paola, R., Scuto, M., Ontario, M. L., Bua, O., … Calabrese, V. (2016). Redox modulation of cellular stress response and lipoxin A4 expression by Hericium erinaceus in rat brain: Relevance to alzheimer’s disease pathogenesis. Immunity & Ageing : I & A, 13, 23. 

Tseng, T. H., Lin, W. L., Chen, Z. H., Lee, Y. J., Shie, M. S., Lee, K. F., … Kuo, H. C. (2016). Moniliformediquinone as a potential therapeutic agent, inactivation of hepatic stellate cell and inhibition of liver fibrosis in vivo. Journal of Translational Medicine, 14(1), 263. 

Tuli, H. S., Sandhu, S. S., & Sharma, A. K. (2014). Pharmacological and therapeutic potential of Cordyceps with special reference to cordycepin. 3 Biotech, 4(1), 1–12. 

Val, C. H., Brant, F., Miranda, A. S., Rodrigues, F. G., Oliveira, B. C. L., Santos, E. A., … Machado, F. S. (2015). Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria. Malaria Journal, 14, 311. 

Valadares, F., Garbi Novaes, M. R. C., & Cañete, R. (2013). Effect of Agaricus sylvaticus supplementation on nutritional status and adverse events of chemotherapy of breast cancer: A randomized, placebo-controlled, double-blind clinical trial. Indian Journal of Pharmacology, 45(3), 217–222. 

Valverde, M. E., Hernández-Pérez, T., & Paredes-López, O. (2015). Edible mushrooms: Improving human health and promoting quality life. International Journal of Microbiology, 2015, 376387. 

Vamanu, E. (2012). Biological activities of the polysaccharides produced in submerged culture of two edible Pleurotus ostreatus mushrooms. Journal of Biomedicine and Biotechnology, 2012, 565974. 

Vazirian, M., Faridfar, S., & Eftekhari, M. (2016). “Gharikon”/”Agharikon” a valuable medicinal mushroom in Iranian traditional medicine. Iranian Journal of Medical Sciences, 41(3 Suppl), S34. 

Vitak, T., Yurkiv, B., Wasser, S., Nevo, E., & Sybirna, N. (2017). Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus. World Journal of Diabetes, 8(5), 187–201. 

Wang, H., Fu, Z., & Han, C. (2013). The medicinal values of culinary-medicinal royal sun mushroom (Agaricus blazei Murrill). Evidence-Based Complementary and Alternative Medicine : eCAM, 2013, 842619. 

Wang, F., Zhou, Z., Ren, X., Wang, Y., Yang, R., Luo, J., & Strappe, P. (2015). Effect of Ganoderma lucidum spores intervention on glucose and lipid metabolism gene expression profiles in type 2 diabetic rats. Lipids in Health and Disease, 14, 49. 

Wang, P. W., Hung, Y. C., Li, W. T., Yeh, C. T., & Pan, T. L. (2016). Systematic revelation of the protective effect and mechanism of Cordycep sinensis on diethylnitrosamine-induced rat hepatocellular carcinoma with proteomics. Oncotarget, 7(37), 60270–60289. 

Wei, W., Shu, S., Zhu, W., Xiong, Y., & Peng, F. (2016). The kinome of edible and medicinal fungus Wolfiporia cocos. Frontiers in Microbiology, 7, 1495. 

Wisitrassameewong, K., Karunarathna, S. C., Thongklang, N., Zhao, R., Callac, P., Moukha, S., … Hyde, K. D. (2012). Agaricus subrufescens: A review. Saudi Journal of Biological Sciences, 19(2), 131–146. 

Wu, J. Y., Chen, X., & Siu, K. C. (2014). Isolation and structure characterization of an antioxidative glycopeptide from mycelial culture broth of a medicinal fungus. International Journal of Molecular Sciences, 15(10), 17318–17332. 

Xu, Z., Chen, X., Zhong, Z., Chen, L., & Wang, Y. (2011). Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities. American Journal of Chinese Medicine, 39(1), 15-27. 

Zhang, J., An, S., Hu, W., Teng, M., Wang, X., Qu, Y., … Wang, D. (2016). The neuroprotective properties of Hericium erinaceus in glutamate-damaged differentiated PC12 Cells and an alzheimer’s disease mouse model. International Journal of Molecular Sciences, 17(11), 1810. 

Zhao, H., Zhang, Q., Zhao, L., Huang, X., Wang, J., & Kang, X. (2012). Spore powder of Ganoderma lucidum improves cancer-related fatigue in breast cancer patients undergoing endocrine therapy: A pilot clinical trial. Evidence-Based Complementary and Alternative Medicine: eCAM, 2012, 809614.

Written by Jessica Davis